CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function
نویسندگان
چکیده
منابع مشابه
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function
Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that these underexplored kinases may have similar functions. Here, we present the crystal structures of human CDKL1, CDKL2, CDKL3, and CDKL5, rev...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2018
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.12.083